1 to Secured Convertible Debentures, dated Jand Amendment No.2 to Secured Convertible Debenture Due December 31, 2010, dated August 7, 2008, and as may be amended, supplemented modified and/or amended and restated from time to time, the “ January 2008 Debenture”) (iii) Secured Convertible Debenture dated Jissued by the Company to the Holder in the original principal amount of $1,000,000 (as amended by Amendment No. Reference is made to that certain (i) Securities Purchase Agreement dated Janu(the “ Securities Purchase Agreement”) between IR Biosciences Holdings, Inc., a Delaware corporation (the “ Company”) and YA Global Investments, L.P., a Cayman Islands exempt limited partnership (the “ Holder”) (ii) Secured Convertible Debenture dated Januissued by the Company to the Holder in the original principal amount of $2,000,000 (as amended by Amendment No.
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